Mouse BACE2 HEK293 Overexpression Lysate MBS8117002 from MyBioSource.com

Description

BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major beta-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid beta protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.

This Mouse BACE2 overexpression lysate was created in HEK293 Cells and intented for use as a Western blot (WB) positive control. Purification of BACE2 protein from the overexpression lysate was verified

Product Specs
ItemMouse BACE2 HEK293 Overexpression Lysate
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS8117002
Format1x Sample Buffer (1x modified RIPA buffer+1x SDS loading buffer).
Modified RIPA Lysis Buffer: 50 mM Tris-HCl pH 7.4, 150 mM NaCl, 1mM EDTA, 1% Triton X-100, 0.1% SDS, 1% Sodium deoxycholate, 1mM PMSF
ApplicationsWestern Blot (WB)
Quantity0.3 mg
Molecular Weight55,800 Da
NCBI Full Gene Namebeta-site APP-cleaving enzyme 2
NCBI Gene AliasesASP21, DRAP, BAE2, 1110059C24Rik, ASP1, ALP56, CEAP1, AEPLC, CDA13, ARP1, AI850424
Molecule NameBACE2
TypeOverexpression Lysate
Domain/Region/TerminusMet1-Pro462
Source/Expression SystemHEK293 Cells
Cell LineHEK293